Now showing items 21-30 of 30
Adenosine Deaminase Activity Is a Sensitive Marker for the Diagnosis of Tuberculous Pleuritis in Patients with Very Low CD4 Counts
(Public Library of Science, 2008-07-30)
Background: Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive ...
Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model
(BioMed Central, 2009-05-18)
Background: We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. This was tested in a mouse model. Methods: Balb/c mice were epicutaneously sensitized with ovalbumin and challenged with ...
p53 protein biosignatures in acute myeloid leukemia
(The University of Bergen, 2006-03-10)
p53 is a tumor suppressor protein often regarded as the guardian of the genome. It is a highly connected protein involved in many signaling processes in the cell. The inactivation of p53 through genetic mutations in TP53 ...
Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazone
(BioMed Central, 2009-03-30)
Background: All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones ...
A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ...
Dietary RNA (s. Cerevisiae) stimulated cytokine secretion in human immune cells: involvement of p38 MAPK, and co-stimulation with LPS or PHA
(The University of Bergen, 2009-07-01)
Dietary nucleotides and nucleic acids are known to affect immune functions in animals and humans, both in vitro and in vivo. In this thesis I wanted to investigate the effect of dietary RNA from baker’s yeast on cytokine ...
Stimulated monocyte IL-6 secretion predicts survival of patients with head and neck squamous cell carcinoma
(BioMed Central, 2008-01-30)
Background This study was performed in order to determine whether monocyte in vitro function is associated with presence, stage and prognosis of head and neck squamous cell carcinoma (HNSCC) disease. Methods Prospective ...
‘‘So you think I’ll survive?’’: a qualitative study about doctor-patient dialogues preceding high-risk cardiac surgery or intervention
(BMJ Publishing Group, 2009)
Objective: To explore doctor-patient interactions and decision-making processes before high-risk cardiac surgery or intervention with special attention to existential challenges. Design, setting and participants: We ...
Airway Inflammation and Bronchial Remodelling in Toluene Diisocyanate-exposed BALB/c Mouse Model
(Blackwell Publishing Ltd., 2007)
Toluene diisocyanate (TDI), a highly reactive industrial chemical, is one of the leading causes of occupation-related asthma in industrialized countries. The pathogenesis of TDI-induced asthma, however, remains not fully ...
Small-Diameter Nerve Fiber Neuropathy in Patients with Systemic Autoimmune Diseases
(The University of Bergen, 2006-10-13)