Now showing items 1-4 of 4
Relationship between Orthostatic Hypotension and White Matter Hyperintensity Load in Older Patients with Mild Dementia
(Public Library of Science, 2012-12-19)
Background/Objectives: White matter hyperintensities (WMH) in magnetic resonance imaging (MRI) scans of the brain, and orthostatic hypotension (OH) are both common in older people. We tested the hypothesis that OH is ...
Susceptibility to chronic mucus hypersecretion, a genome wide association study
Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. ...
Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ...
Investigation of complement component C4 copy number variation in human longevity
Genetic factors have been estimated to account for about 25% of the variation in an adult’s life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences ...