Now showing items 1-5 of 5
Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes
(BioMed Central, 2009-08-21)
Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated genes into ...
Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons
(Oxford University Press (OUP), 2009-12-06)
Using a comparative genomics approach to reconstruct the fate of genomic regulatory blocks (GRBs) and identify exonic remnants that have survived the disappearance of their host genes after whole-genome duplication (WGD) ...
Ancora: a web resource for exploring highly conserved noncoding elements and their association with developmental regulatory genes
(BioMed Central, 2008-02-12)
Metazoan genomes contain arrays of highly conserved noncoding elements (HCNEs) that span developmental regulatory genes and define regulatory domains. We describe Ancora http:// ancora.genereg.net, a web resource that ...
Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes
(BioMed Central, 2007-10-31)
A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovered areas around ...
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates
(Cold Spring Harbor Laboratory Press, 2007-03-06)
We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding ...