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Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase
(BioMed Central, 2009-10-19)
Background The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region ...
HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain
(BioMed Central, 2005-06-10)
Background: The HIV-1 Rev regulatory protein binds as an oligomeric complex to viral RNA mediating nuclear export of incompletely spliced and non-spliced viral mRNAs encoding the viral structural proteins. However, the ...