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dc.contributor.authorZuo, Huieng
dc.contributor.authorTell, Grethe Seppolaeng
dc.contributor.authorVollset, Stein Emileng
dc.contributor.authorUeland, Per Magneeng
dc.contributor.authorNygård, Ottareng
dc.contributor.authorMidttun, Øivindeng
dc.contributor.authorMeyer, Klauseng
dc.contributor.authorUlvik, Arveeng
dc.contributor.authorEussen, Simoneeng
dc.date.accessioned2014-12-11T10:47:11Z
dc.date.available2014-12-11T10:47:11Z
dc.date.issued2014-06-19eng
dc.identifier.issn0008-543Xeng
dc.identifier.urihttp://hdl.handle.net/1956/8912
dc.description.abstract<p>Background It has been reported that interferon-&gamma; (IFN-&gamma;)&ndash;induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor of poor prognosis. However, whether baseline levels of these makers are associated with subsequent cancer risk in the general population remains unknown.</p> <p>Methods We conducted a prospective analysis of the Hordaland Health Study in 6594 adults without known cancer at baseline who were enrolled between April 1998 and June 1999. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using multivariate Cox proportional hazards regression models adjusted for sex, age, body mass index, smoking status, and renal function.</p> <p>Results A total of 971 incident cancer cases (507 men and 464 women) were identified over a median follow-up time of 12 years. Baseline plasma neopterin, KTR and C-reactive protein (CRP) were significantly associated with an increased risk of overall cancer in models adjusted for covariates (P for trend across quartiles&thinsp;=&thinsp;.006 for neopterin, .022 for KTR, and .005 for CRP). The multivariate-adjusted HR (95% CI) per SD increment in similar models were 1.09 (1.03-1.16) for neopterin, 1.07 (1.01-1.14) for KTR, and 1.04 (0.98-1.10) for CRP. The associations between the inflammatory markers and risk of major specific cancer types were also provided.</p> <p>Conclusions Our findings indicate that plasma neopterin, KTR, and CRP are associated with a significantly increased risk of overall cancer. Our study revealed novel evidence regarding the role of IFN-&gamma;&ndash;induced inflammation in human carcinogenesis.</p>en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.subjectimmune activationeng
dc.subjectInflammationeng
dc.subjectNeopterineng
dc.subjectkynurenine-to-tryptophan ratioeng
dc.subjectCRPeng
dc.subjectCancereng
dc.subjectRiskeng
dc.subjectCohort studyeng
dc.titleInterferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Studyeng
dc.typeJournal articleeng
dc.rights.holderCopyright 2014 The Authors
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleCancereng
bibo.volume120eng
bibo.issue21eng
bibo.pageStart3370eng
bibo.pageEnd3377eng
bibo.doihttp://dx.doi.org/10.1002/cncr.28869eng
bora.accessRightsinfo:eu-repo/semantics/openAccesseng
dc.identifier.cristinID1224998eng
dc.identifier.doi10.1002/cncr.28869
bora.bpoaIDbpoa149


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