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  • Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling 

    Forsse, David Erik; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Viste, Kristin; Almås, Bjørg; Bertelsen, Bjørn-Erik; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Elsevier, 2020-02)
    Objective Blood-based biomarkers are attractive due to ease of sampling and standardized measurement technology, reducing obstacles to clinical implementation. The objective of this study was to evaluate a clinically ...
    Journal article
  • Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation 

    Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Maeland, Steffen; O'Connell, Kevin S.; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Dale, Anders (Springer Nature, 2019-06-03)
    Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, ...
    Journal article
  • Nausea and vomiting of pregnancy and hyperemesis gravidarum 

    Fejzo, Marlena Schoenberg; Trovik, Jone; Grooten, Iris J.; Sridharan, Kannan; Roseboom, Tessa J.; Vikanes, Åse Vigdis; Painter, Rebecca C.; Mullin, Patrick M. (Nature, 2019)
    Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe ...
    Journal article
  • Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery 

    Mikalsen, Solveig Meyer; Bjørke-Monsen, Anne Lise; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan (Elsevier, 2019)
    Purpose Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Increased blood Pb levels have been reported after ...
    Journal article
  • The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation 

    Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Frontiers, 2019-05-08)
    Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ...
    Journal article
  • Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma 

    Hanes, Robert; Munthe, Else; Grad, Iwona; Han, Jianhua; Karlsen, Ida Tveit; Mc Cormack, Emmet; Meza-Zepeda, Leonardo A.; Stratford, Eva Wessel; Myklebost, Ola (MDPI, 2019-02-21)
    Background: FGFR inhibition has been proposed as treatment for dedifferentiated liposarcoma (DDLPS) with amplified FRS2, but we previously only demonstrated transient cytostatic effects when treating FRS2-amplified DDLPS ...
    Journal article
  • Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease 

    Stiglund, Natalie; Strand, Kristina; Cornillet, Martin; Stål, Per; Thorell, Anders; Zimmer, Christine L.; Näslund, Erik; Karlgren, Silja; Nilsson, Henrik; Mellgren, Gunnar; Fernø, Johan; Hagström, Hannes; Björkström, Niklas K. (Frontiers, 2019-06-04)
    Non-alcoholic fatty liver disease (NAFLD), and the progressive stage non-alcoholic steatohepatitis (NASH), is the predominant cause of chronic liver disease globally. As part of the complex pathogenesis, natural killer ...
    Journal article
  • Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise 

    Kleiven, Øyunn; Omland, Torbjørn; Skadberg, Øyvind; Melberg, Tor Harald; Bjørkavoll-Bergseth, Magnus; Auestad, Bjørn Henrik; Bergseth, Rolf; Greve, Ole Jacob; Aakre, Kristin Moberg; Ørn, Stein (Sage, 2019)
    Background: Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring cardiac troponin I and T (cTnI and cTnT) after strenuous exercise ...
    Journal article
  • Motivation and response rates in bronchoscopy studies 

    Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal; Leiten, Elise Orvedal; Nordeide, Eli; Bakke, Per S.; Lehmann, Sverre; Nielsen, Rune (Springer, 2019-05-02)
    Background Bronchoscopy is frequently used to sample the lower airways in lung microbiome studies. Despite being a safe procedure, it is associated with discomfort that may result in reservations regarding participation ...
    Journal article
  • Optic nerve constraints for carbon ion RT at CNAO ? Reporting and relating outcome to European and Japanese RBE 

    Dale, Jon Espen; Molinelli, Silvia; Vitolo, Viviana; Vischioni, Barbara; Bonora, Maria; Magro, Giuseppe; Pettersen, Helge Egil Seime; Mairani, Andrea; Hasegawa, Azusa; Dahl, Olav; Valvo, Francesca; Fossati, Piero (Elsevier, 2019)
    Background and purpose: Until now, carbon ion RT (CIRT) dose constraints for the optic nerve (ON) have only been validated and reported in the NIRS RBE-weighted dose (DNIRS). The aim of this work is to improve CNAO’s ...
    Journal article
  • The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer 

    Helland, Øystein; Popa, Mihaela Lucia; Bischof, Katharina; Gjertsen, Bjørn Tore; McCormack, Emmet; Bjørge, Line (Public Library of Science (PLOS), 2016-06-28)
    Background: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the ...
    Journal article
  • Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: A multicenter cohort study 

    Carlsen, Esben Andreas; Fazio, Nicola; Granberg, Dan; Grozinsky-Glasberg, Simona; Ahmadzadehfar, Hojjat; Grana, Chiara Maria; Zandee, Wouter T.; Cwikla, Jaroslaw; Walter, Martin A.; Oturai, Peter Sandor; Rinke, Anja; Weaver, Andrew; Frilling, Andrea; Gritti, Sara; Arveschoug, Anne Kirstine; Meirovitz, Amichay; Knigge, Ulrich; Sorbye, Halfdan (Bioscientifica, 2019)
    Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1–2 (G1–G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms ...
    Journal article
  • Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations 

    Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Einevoll, Gaute (Oxford University Press, 2019-02)
    Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ...
    Journal article
  • Altered development of fetal liver perfusion in pregnancies with pregestational diabetes 

    Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Kiserud, Torvid; Hanson, Mark; Kessler, Jørg (PLOS, 2019-03-13)
    Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ...
    Journal article
  • Physical activity, exercise and cardiac troponins: Clinical implications 

    Aakre, Kristin Moberg; Omland, Torbjørn (Elsevier, 2019)
    Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are ...
    Journal article
  • Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy 

    Larsen, Alf Inge; Valborgland, Torstein; Ogne, Christer; Lindal, Sigurd; Halvorsen, Bente; Munk, Peter Scott; Kvaløy, Jan Terje; Aukrust, Pål; Yndestad, Arne (Sage, 2019)
    Chronic heart failure (CHF) is characterized by inflammation and skeletal muscle myopathy, including impaired fibre type distribution and reduced capillary density, reduced cytochrome oxidase activity and reduced mitochondrial ...
    Journal article
  • Poor outcome in hypoxic endometrial carcinoma is related to vascular density 

    Reijnen, Casper; van Weelden, Willem Jan; Arts, Martijn S.J.P.; Peters, Johan P.; Rijken, Paul F.; van de Vijver, Koen; Santacana, Maria; Bronsert, Peter; Bulten, Johan; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Reques, Armando; Mancebo, Gemma; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Minar, Lubos; Jandakova, Eva; Snijders, Marc P.L.M.; van den Berg-van Erp, Saskia; Küsters-Vandevelde, Heidi V.N.; Matias-Guiu, Xavier; Amant, Frederic; Massuger, Leon F.A.G.; Bussink, Johan; Pijnenborg, Johanna M.A. (Springer Nature, 2019-04-23)
    Background Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Methods Tumour ...
    Journal article
  • Sex-related change in BMI of 15- to 16-year-old Norwegian girls in cross-sectional studies in 2002 and 2017 

    Bjertnæs, Asborg Sine Aanstad; Grundt, Jacob Holter; Juliusson, Petur Benedikt; Markestad, Trond Jacob; Strand, Tor A; Holten-Andersen, Mads Nikolaj (Springer, 2019-11-12)
    Background: The prevalence of overweight and obesity (OWOB) has stabilized in some countries, but a portion of children with high body mass index (BMI) may have become heavier. This study aimed to describe the distributions of ...
    Journal article
  • Airway symptoms and atopy in young children prescribed asthma medications: A large‐scale cohort study 

    Mikalsen, Ingvild Bruun; Dalen, Ingvild; Karlstad, Øystein; Eide, Geir Egil; Magnus, Maria Christine; Nystad, Wenche; Øymar, Knut (Wiley, 2019)
    Diagnosing asthma and deciding treatment are difficult in young children. An inappropriate and too high prescription rate of inhaled corticosteroids (ICS) is suggested, but how airway symptoms are associated with prescriptions ...
    Journal article
  • Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: an observational study in Ethiopia 

    Zangenberg, Mike; Johansen, Øystein Haarklau; Abdissa, Alemseged; Eshetu, Beza; Kurtzhals, Jørgen Anders; Friis, Henrik; Sommerfelt, Halvor; Langeland, Nina; Hanevik, Kurt (Wiley, 2019)
    Objectives: To assess the prevalence of prolonged and persistent diarrhoea, to estimate their co‐occurrence with acute malnutrition and association with demographic and clinical factors. Methods: Case–control study ...
    Journal article

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