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  • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

    Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Nature Research, 2019-07-01)
    Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...
    Journal article
  • Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681 

    Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (MDPI, 2019-06-22)
    Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ...
    Journal article
  • Modes of e-Health delivery in secondary prevention programmes for patients with coronary artery disease: A systematic review 

    Brørs, Gunhild; Pettersen, Trond Røed; Hansen, Tina B.; Fridlund, Bengt Gotthard Anton; Hølvold, Linn Benjaminsen; Lund, Hans; Norekvål, Tone M. (BioMed Central, 2019-06-10)
    Background: Electronic health (e-Health) interventions are emerging as an effective alternative model for improving secondary prevention of coronary artery disease (CAD). The aim of this study was to describe the effectiveness ...
    Journal article
  • Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia 

    Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre; Kopperud, Reidun Kristin; Sjøholt, Gry; Bruserud, Øystein; McCormack, Emmet; Gjertsen, Bjørn Tore (Springer Nature, 2019)
    Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ...
    Journal article
  • Investigation of perioperative work processes in provision of antibiotic prophylaxis: a prospective descriptive qualitative study across surgical specialties in Norway 

    Harthug, Stig; Søfteland, Eirik; Haugen, Arvid Steinar; Sevdalis, Nick; Smith, Ingrid; Wiig, Siri; Aase, Karina; Wæhle, Hilde Valen (BMJ, 2019)
    Abstract Objective: Surgical site infections are known postoperative complications, yet the most preventable of healthcare-associated infections. Correct provision of surgical antibiotic prophylaxis (SAP) is crucial. Use ...
    Journal article
  • Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes 

    Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders M; Andreassen, Ole Andreas (Frontiers Media, 2019-03-13)
    Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD ...
    Journal article
  • Biomarkers of one-carbon metabolism and B-vitamin status : Targeted metabolomics in rats and humans exploring the effects of PPARα-activation and dietary composition 

    Lysne, Vegard (The University of Bergen, 2019-10-04)
    BACKGROUND: One-carbon metabolism is an overarching term describing central metabolic pathways involved in the transfer of one-carbon units. These include the methionine-homocysteine and folate cycles, as well as the ...
    Doctoral thesis
  • Discovery of shared genomic loci using the conditional false discovery rate approach 

    Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders; Andreassen, Ole Andreas (Springer Berlin Heidelberg, 2019-09-13)
    In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic ...
    Journal article
  • Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease 

    Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga; Nygård, Ottar (Springer Berlin Heidelberg, 2019-09-09)
    Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ...
    Journal article
  • Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium 

    Muller, David C.; Larose, Tricia L; Hodge, Allison; Guida, Florence; Langhammer, Arnulf; Grankvist, Kjell; Meyer, Klaus; Cai, Qiuyin; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Albanes, Demetrius; Giles, Graham G.; Sesso, Howard D.; Lee, I-Min; Gaziano, J. Michael; Yuan, Jian-Min; Hoffman Bolton, Judith; Buring, Julie E.; Visvanathan, Kala; Le Marchand, Loic; Purdue, Mark P.; Caporaso, Neil E.; Midttun, Øivind; Ueland, Per Magne; Prentice, Ross L.; Weinstein, Stephanie J.; Stevens, Victoria L.; Zheng, Wei; Blot, William J.; Shu, Xiao-Ou; Zhang, Xuehong; Xiang, Yong-Bing; Koh, Woon-Puay; Hveem, Kristian; Thomson, Cynthia A.; Pettinger, Mary; Engström, Gunnar; Brunnström, Hans; Milne, Roger L.; Stampfer, Meir J.; Han, Jiali; Johansson, Mikael; Brennan, Paul; Severi, Gianluca; Johansson, Mattias (BMJ Publishing Group, 2019-01-03)
    Objectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but ...
    Journal article
  • The PI3K-Akt-mTOR intracellular signaling pathway in human acute myeloid leukemia 

    Nepstad, Ina (The University of Bergen, 2019-03-08)
    Acute myeloid leukemia (AML) is a heterogeneous malignancy where disruption of normal intracellular signaling occurs due to mutations or abnormal external signaling. Many pathways have emerged as potential targets for ...
    Doctoral thesis
  • Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats 

    Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Hindawi Publishing, 2011-09-06)
    This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ...
    Journal article
  • Burden and characteristics of the comorbidity tuberculosis - diabetes in Europe : TBnet prevalence survey and case-control study 

    Sane Schepisi, Monica; Navarra, Assunta; Altet Gómez, Maria de las Nieves; Dudnyk, Andrii; Dyrhol-Riise, Anne Ma; Esteban, Jaime; Giorgetti, Pier Francesco; Gualano, Gina; Guglielmetti, Lorenzo; Heyckendorf, Jan; Kaluzhenina, Anna; Lange, Berit; Lange, Christoph; Manika, Katerina; Miah, Jalal; Nanovic, Zorica; Pontali, Emanuele; Prego, Monica Rios; Solovič, Ivan; Tiberi, Simon; Palmieri, Fabrizio; Girardi, Enrico (Oxford University Press, 2019-01)
    Background: The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment ...
    Journal article
  • Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows 

    Verheggen, Kenneth; Ræder, Helge; Berven, Frode; Martens, Lennart Martens; Barsnes, Harald; Vaudel, Marc (Wiley, 2017-09-13)
    Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass ...
    Journal article
  • Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018 

    Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca Jane; Tenson, Tanel; Merits, Andres; Kainov, Denis (MDPI, 2019-03-01)
    With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ...
    Journal article
  • PCR based Malaria diagnostics : – Method development and application 

    Haanshuus, Christel Gill (The University of Bergen, 2019-11-12)
    Background Almost half of the world’s population is at risk of malaria. Malaria is a parasitic vector borne disease spread by infected female Anopheles mosquitos. The protozoan parasite belongs to the genus Plasmodium ...
    Doctoral thesis
  • Adaptive computerized working memory training in patients with mild cognitive impairment. A randomized double-blind active controlled trial 

    Flak, Marianne Møretrø; Hol, Haakon Ramsland; Hernes, Susanne M S; Chang, Linda; Engvig, Andreas; Bjuland, Knut Jørgen; Pripp, Are Hugo; Madsen, Bengt-Ove; Knapskog, Anne Brita; Ulstein, Ingun; Lona, Trine Eli.B.; Skranes, Jon Sverre; Løhaugen, Gro (Frontiers Media, 2019-04-12)
    Objective: We investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions ...
    Journal article
  • A Potential Golden Age to Come-Current Tools, Recent Use Cases, and Future Avenues for De Novo Sequencing in Proteomics 

    Muth, Thilo; Hartkopf, Felix; Vaudel, Marc; Renard, Bernhard Y (Wiley, 2018-07-02)
    In shotgun proteomics, peptide and protein identification is most commonly conducted using database search engines, the method of choice when reference protein sequences are available. Despite its widespread use the ...
    Journal article
  • Live Attenuated Influenza Vaccine (LAIV) Immunization in Children and Adults: Lesson for Development of Universal Influenza Vaccine 

    Islam, Shahinul (The University of Bergen, 2019-11-06)
    According to the WHO (World Health Organization), one billion peoples are infected annually of whom three to five millions become severely ill and 250-500 000 deaths worldwide (He, Wang et al. 2013) although the latest ...
    Doctoral thesis
  • NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity 

    Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne (Frontiers, 2019-07-16)
    Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ...
    Journal article

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