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dc.contributor.authorStrand, Elineng
dc.contributor.authorBjørndal, Bodileng
dc.contributor.authorNygård, Ottareng
dc.contributor.authorBurri, Lenaeng
dc.contributor.authorBerge, Christeng
dc.contributor.authorBohov, Pavoleng
dc.contributor.authorChristensen, Bjørn Josteineng
dc.contributor.authorBerge, Kjetileng
dc.contributor.authorWergedahl, Hegeeng
dc.contributor.authorViste, Asgauteng
dc.contributor.authorBerge, Rolf Kristianeng
dc.date.accessioned2013-05-19T09:19:51Z
dc.date.available2013-05-19T09:19:51Z
dc.date.issued2012-06-27eng
dc.identifier.citationLipids in Health and Disease 2012, 11:82eng
dc.identifier.issn1476-511Xeng
dc.identifier.urihttp://hdl.handle.net/1956/6624
dc.description.abstract<p>Background: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated fatty acids (PUFA) has been associated with improved left ventricular function and functional capacity in patients with dilated cardiomyopathy. We investigated the long-term effects of the pan-PPAR agonist tetradecylthioacetic acid (TTA) and/or high-dose fish oil (FO) on cardiac fatty acid (FA) composition and lipid metabolism. Male Wistar rats were given one out of four different 25% (w/v) fat diets: control diet; TTA diet; FO diet; or diet containing both TTA and FO.</p> <p>Results: After 50 weeks n-3 PUFA levels were increased by TTA and FO in the heart, whereas liver levels were reduced following TTA administration. TTA was associated with a decrease in arachidonic acid, increased activities of carnitine palmitoyltransferase II, fatty acyl-CoA oxidase, glycerol-3-phosphate acyltransferase, and fatty acid synthase in the heart. Furthermore, cardiac Ucp3 and Cact mRNA was upregulated.</p> <p>Conclusions: Long-term treatment with the pan-PPAR agonist TTA or high-dose FO induced marked changes in PUFA composition and enzymatic activity involved in FA metabolism in the heart, different from liver. Changes included increased FA oxidation and a selective increase in cardiac n-3 PUFA.</p>eng
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/7112" target="blank">Bioactive fatty acids and coronary heart disease. Mechanisms and clinical effects of dietary fatty acids</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/eng
dc.subjectHeart metabolismeng
dc.subjectPeroxisome proliferator-activated receptoreng
dc.subjectPolyunsaturated fatty acidseng
dc.subjectTetradecylthioacetic acideng
dc.titleLong-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rateng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.rights.holderCopyright 2012 Strand et al.; licensee BioMed Central Ltd.
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleLipids in Health and Diseaseeng
bibo.volume11eng
bibo.doihttp://dx.doi.org/10.1186/1476-511X-11-82eng
dc.identifier.cristinID964326eng
dc.identifier.doi10.1186/1476-511x-11-82
dcterms.isPartOfhttp://hdl.handle.net/1956/7112


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