Show simple item record

dc.contributor.authorStrand, Elineng
dc.contributor.authorBjørndal, Bodileng
dc.contributor.authorNygård, Ottareng
dc.contributor.authorBurri, Lenaeng
dc.contributor.authorBerge, Christeng
dc.contributor.authorBohov, Pavoleng
dc.contributor.authorChristensen, Bjørn Josteineng
dc.contributor.authorBerge, Kjetileng
dc.contributor.authorWergedahl, Hegeeng
dc.contributor.authorViste, Asgauteng
dc.contributor.authorBerge, Rolf Kristianeng
dc.identifier.citationLipids in Health and Disease 2012, 11:82eng
dc.description.abstract<p>Background: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated fatty acids (PUFA) has been associated with improved left ventricular function and functional capacity in patients with dilated cardiomyopathy. We investigated the long-term effects of the pan-PPAR agonist tetradecylthioacetic acid (TTA) and/or high-dose fish oil (FO) on cardiac fatty acid (FA) composition and lipid metabolism. Male Wistar rats were given one out of four different 25% (w/v) fat diets: control diet; TTA diet; FO diet; or diet containing both TTA and FO.</p> <p>Results: After 50 weeks n-3 PUFA levels were increased by TTA and FO in the heart, whereas liver levels were reduced following TTA administration. TTA was associated with a decrease in arachidonic acid, increased activities of carnitine palmitoyltransferase II, fatty acyl-CoA oxidase, glycerol-3-phosphate acyltransferase, and fatty acid synthase in the heart. Furthermore, cardiac Ucp3 and Cact mRNA was upregulated.</p> <p>Conclusions: Long-term treatment with the pan-PPAR agonist TTA or high-dose FO induced marked changes in PUFA composition and enzymatic activity involved in FA metabolism in the heart, different from liver. Changes included increased FA oxidation and a selective increase in cardiac n-3 PUFA.</p>eng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="" target="blank">Bioactive fatty acids and coronary heart disease. Mechanisms and clinical effects of dietary fatty acids</a>eng
dc.rightsAttribution CC BYeng
dc.subjectHeart metabolismeng
dc.subjectPeroxisome proliferator-activated receptoreng
dc.subjectPolyunsaturated fatty acidseng
dc.subjectTetradecylthioacetic acideng
dc.titleLong-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rateng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.rights.holderCopyright 2012 Strand et al.; licensee BioMed Central Ltd.
bora.peerreviewedPeer reviewedeng
bora.journalTitleLipids in Health and Diseaseeng

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY