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dc.contributor.authorNæss, Areen_US
dc.contributor.authorAndreeva, Hristina D.en_US
dc.contributor.authorSørnes, Steinaren_US
dc.date.accessioned2013-05-02T13:34:27Z
dc.date.available2013-05-02T13:34:27Z
dc.date.issued2011eng
dc.identifier.citationActa Pharmaceutica 61(3): 297-302eng
dc.identifier.issn1330-0075
dc.identifier.urihttp://hdl.handle.net/1956/6554
dc.description.abstractTigecycline achieves high intracellular concentrations in polymorphonuclear leukocytes (PMNs). To evaluate the effects of tigecycline on human PMNs, PMNs were incubated with tigecycline dilutions (0.1 to 100 mg L–¹). Phagocytosis- associated PMN Fcg- and complement receptors as well as phagocytosis and oxidative burst induced by Staphylococcus aureus were measured by flow cytometry. Incubation with tigecycline caused small but significant decreases in the density of complement receptors CD11b and CD35 (all concentrations) and Fcg receptors CD16 and CD32 (high concentrations), but not in the percentages of receptor-bearing cells, except for small reductions in the proportions of CD16 positive cells at high concentrations. Tigecycline had no effect on phagocytosis or oxidative burst induced by S. aureus. Tigecycline was thus associated with decreased density of PMN complement and (at high concentrations) Fcg receptors. Although statistically significant, the differences were small and did not influence the PMN function as measured by phagocytosis and oxidative burst.en_US
dc.language.isoengeng
dc.publisherDe Gruytereng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.subjectTigecyclineeng
dc.subjectLeukocyteeng
dc.subjectPhagocytosiseng
dc.subjectOxidative bursteng
dc.titleTigecycline attenuates polymorphonuclear leukocyte (PMN) receptors but not functionsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.identifier.doihttps://doi.org/10.2478/v10007-011-0024-4
dc.source.issue3
dc.source.journalActa Pharmaceutica
dc.source.pagenumber297-302
dc.source.volume61


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